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The International Course on the Clinical Management of Drug-Resistant Tuberculosis is an online training course, consisting of on-demand videos, quizzes, discussions and practical exercises, aiming to strengthen participants’ capacity in the clinical and programmatic management of drug-resistant tuberculosis.

For the 2023 edition of the course, completion of the online materials is optional. There is an in-person session from the 4th to the 8th December 2023 in Taipei, Taiwan. The in-person session is being organised in partnership with Wan Fang Hospital Taipei Medical University, Taiwan Anti-TB Association and Taiwan CDC.

Module 1

  • Principles of TB care and prevention
  • TB: The organism and the host
  • Basic concepts of drug-resistance in TB
  • Global epidemiology of drug-resistant TB and contributing factors
  • Clinical and radiographic manifestations of TB and drug-resistant TB
  • Conventional anti-TB drug susceptibility testing
  • Rapid diagnosis of drug-resistant TB: Xpert
  • Rapid diagnosis of drug-resistant TB: Line probe assay

Module 2

  • Case finding of drug-resistant TB
  • Treatment of new and previously treated TB, isoniazis resistant TB
  • Treatment of rifampicin-resistant TB: long regimen and fluoroquinolone
  • Bedaquiline, linezolid, Clofazimine
  • Delamanid, Pretomanid, Imipenem/Meropenem
  • Short course chemotherapy for MDR-TB
  • HIV and MDR-TB: clinical manifestations and diagnosis
  • Management of DR-TB among people living with HIV

Module 3

  • Active tuberculosis drug safety monitoring and management (aDSM)
  • Management of adverse drug reactions
  • Management of DR-TB in patients with liver disease, renal insufficiency and pregnancy
  • MDR-TB in children and management of contact of DR-TB
  • Surgical intervention in the management of MDR- and XDR-TB
  • Care and support for patients with MDR/RR-TB
  • Infection control - minimal requirements
  • Management of drug-resistant TB in the era of COVID-19

At the end of this course, participants will be able to:

  • Describe the current global epidemiological situation of drug-resistant tuberculosis
  • Review the different approaches for the detection and diagnosis of drug-resistant tuberculosis
  • Address the basics of ideal treatment, according to different patterns of drug-resistance
  • Review second-line medicines and new drugs
  • Discuss common problems and possible solutions for programmatic management of drug-resistant tuberculosis

This course is designed for clinicians, who are responsible for diagnosis and treatment of drug-resistant tuberculosis, staff of national tuberculosis programmes and technical partners, working in tuberculosis care and prevention, in low- and middle-income countries, especially in settings where programmatic management of drug-resistant tuberculosis (PMDT) had been or is going to be implemented.

The completion of the online materials is optional for the 2023 edition of this course.

The in-person session will take place from the 4th to the 8th December 2023 in Taipei, Taiwan.

The in-person session is being organised in partnership with Wan Fang Hospital Taipei Medical University, Taiwan Anti-TB Association and Taiwan CDC.

Pre-assessment
Week 1 | Part 1
Week 1 | Part 2
Week 2 | Part 1
Week 2 | Part 2
Week 3 | Part 1
Week 3 | Part 2
Assessment and Evaluation

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